Derivatives of 4-amino 3-carboxy naphthyridines and their pharma

Details Derivatives of 4-amino 3-carboxy naphthyridines and their pharma Derivatives of 4-amino 3-carboxy naphthyridines and their pharma

1989-06-06

1991-02-26

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514183, 514212, 540481, 540597, 546122, 546123, A61K 3144, C07D47104

Patent

active

049962132

ABSTRACT:
Compounds represented by the general formula ##STR1## in which R.sub.1 and R.sub.2 are independently selected from hydrogen, C.sub.1 -C.sub.6 alkyl, phenyl or benzyl, or R.sub.1 and R.sub.2 may form together with the nitrogen atom to which they are attached a C.sub.4 -C.sub.8 saturated heterocycle, R.sub.3 and R.sub.4 are independently selected from hydrogen or C hd 1-C.sub.6 alkyl, R.sub.5 is selected from hydrogen or halogen, or C.sub.1 -C.sub.4 alkyl, C.sub.1 -C hd 4 alkoxy, nitro or trifluoromethyl, n is 1, 2 or 3, and one of the symbols A, B, C or D represents N and the others represent CH, as well as the N-oxids and the the pharmaceutically acceptable acid addition salts and their salts with bases. The compounds have nervous system affecting properties.

REFERENCES:
R. M. Titkova et al., "Synthesis of 4-substituted 3-carbethoxy [carboxy]-1,5-naphthyridines, Their Properties and Biological Activity", vol. 97, No. 19, Nov. 8, 1982, p. 706, No. 162862n.

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