Derivatives of 4-(2,4-difluorbiphenylyl)-2-methyl-4-oxobutanoic

Details Derivatives of 4-(2,4-difluorbiphenylyl)-2-methyl-4-oxobutanoic Derivatives of 4-(2,4-difluorbiphenylyl)-2-methyl-4-oxobutanoic

1991-06-17

1993-01-05

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

560 51, 562459, 564169, C07C 5988, C07C 69738, C07C23534, C07D295192

Patent

active

051772043

ABSTRACT:
This relates to substances represented by formula (I), wherein X stands for represented by either OR in which R is an alkyl of 1 to 4 carbon atoms, or NHR in which is an alkyl of 1 to 4 carbon atoms, or a (CH.sub.2).sub.n NR.sub.2 group wherein n is 2 or 3 while R.sup. is an methyl or an ethyl group; eventually X may represent morpholinyl. Also considered are salts of 4-(2,4-difluorbiphenylyl)-2-methyl-4-oxobutanoic acid with appropriate inorganic or organic bases represented by formula (II) wherein B.sup.+ is either an alkaline metal cation, alkaline earth metal cation, cyclohexylamine cation, or lysine cation. Said substances are characterized by antiinflamatory properties comparable to (and greater than) the initial acid while simultaneously said modifications of their physico-chemical properties broaden the posibilities of their therapeutic application. ##STR1##

REFERENCES:
patent: 4683331 (1987-07-01), Kuchar

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