Derivatives of 3-amino-pregn-5-ene

Details Derivatives of 3-amino-pregn-5-ene Derivatives of 3-amino-pregn-5-ene

1982-10-25

1984-04-24

Roberts, Elbert L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2603973, 2603975, A61K 3156

Patent

active

044447671

ABSTRACT:
A compound selected from the group consisting of: 3-amino-.DELTA..sup.5 -pregnenes of the formula I: ##STR1## wherein X is selected from the group of ##STR2## the wavy lines indicate that the group may be in the .alpha.-or .beta.-position, R.sub.1 is selected from the group consisting of hydrogen and hydroxyalkyl or 2 to 5 carbon atoms, R.sub.2 is selected from the group consisting of hydrogen, hydroxyalkyl of 2 to 5 carbon atoms, acyl of an aliphatic carboxylic acid of 3 to 8 carbon atoms, alkoxycarbonyl of 2 to 8 carbon atoms, acyl of an .alpha.-amino-carboxylic acid or from a peptide of 2 to 3 amino acids of which amines may be either unsubstituted or mono-or disubstituted with alkyl of 1 to 5 carbon atoms with the proviso that R.sub.1 and R.sub.2 are not both hydrogen and that if the 3-amino group is in the .beta.-position, (i) when X is ##STR3## R.sub.1 and R.sub.2 are not both hydroxyethyl or (ii) when X is ##STR4## and R.sub.1 is hydrogen, R.sub.2 is not ethoxycarbonyl, the compound of the formula I wherein X is ##STR5## R.sub.1 is hydrogen and R.sub.2 is methyl, the 3-amino group is in the .alpha.-position
and their non-toxic, pharmaceutically acceptable acid addition salts which are useful as stimulants of the mammalian immune system.

REFERENCES:
Chem. Abstracts, vol. 95, (1981) Par. 151001p Article by Frappier et al., J. Org. Chem. 1981, No. 46 (21) pp. 4314-4315.

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