Derivatives of 3,3-bis-(4-hydroxyphenyl)-2-indolinone and proces

Details Derivatives of 3,3-bis-(4-hydroxyphenyl)-2-indolinone and proces Derivatives of 3,3-bis-(4-hydroxyphenyl)-2-indolinone and proces

1975-05-01

1977-10-11

Love, Ethel G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D20934

Patent

active

040534839

ABSTRACT:
This invention relates to a group of compounds derived from 3,3-bis-(4-hydroxyphenyl)-2-indolinone having an effective laxative activity. The process for their preparation comprises reacting a substituted 3,3-bis-(4-hydroxyphenyl)-2-indolinone with a compound of the group comprising ethyl chloroformiate, chloracetyl chloride, acetyl chloride, acetyl anhydride, propionyl chloride, propionyl anhydride and chlorosulphonic acid (in pyridine).

REFERENCES:
patent: 3901912 (1975-08-01), Brugzese et al.
Garrido et al., Eur. J. Med. Chem., Mar., 1975, No. 2 pp. 142-146.
Moreto et al., Eur. Journ. Pharmacology, 36(1), Mar. 1976, pp. 221-226.
Queralt et al., Archiv de Farm. Y Toxicol., 1(2), Aug. 1975, pp. 137-146.
Wexler et al., "Chem. Abstracts," vol. 69, p. 9977, No. 106, 525g (1968).
Wexler, "Chem. Abstracts," vol. 58, p. 3379g and subject index, p. 1149s (1963).

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