Derivatives of 2-(substituted sulfamyl)-6-nitrobenzoic acids, us

Details Derivatives of 2-(substituted sulfamyl)-6-nitrobenzoic acids, us Derivatives of 2-(substituted sulfamyl)-6-nitrobenzoic acids, us

1987-06-01

1989-07-11

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

A61K 3124

Patent

active

048472948

ABSTRACT:
Derivatives of 2-(Substituted sulfamyl) 6-nitrobenzoic acids are disclosed, wherein at least one of the sulfamyl substituents is selected from amino-(lower alkyl), (lower alkyl)-amino-(lower alkyl), or di(lower alkyl)-amino-(lower alkyl), hydrogen, lower alkyl, hydroxy-(lower alkyl), allyl, or when taken together with the nitrogen of the sulfamyl moiety, form a heterocyclic ring. These compounds have activity in increasing the sensitivity of hypoxic tumor cells to therapeutic radiation. Also disclosed are methods of preparing such compounds and pharmaceutical compositions including such compounds.

REFERENCES:
patent: 4603133 (1986-07-01), Englehardt et al.
patent: 4647588 (1987-03-01), Englehardt et al.
patent: 4654369 (1987-05-01), Saari
patent: 4694020 (1985-09-01), Englehardt et al.
patent: 4731369 (1988-03-01), Englehardt et al.
Haliwell, B. et al. Free Redicals in Biology and Medicine, Oxford 1985, pp. 238-241.
Narayanan, V. L. et al., Development of Radiosensitizers, 19 pp. 174-175 (1982).
Wardman, P. Radiation Chemistry in the Clinic: Hypoxic Cell Radiosenisitizers for Radiotherapy.

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