Derivatives of 2-(substituted sulfamyl)-6-nitrobenzoic acids and

Details Derivatives of 2-(substituted sulfamyl)-6-nitrobenzoic acids and Derivatives of 2-(substituted sulfamyl)-6-nitrobenzoic acids and

1986-10-21

1987-09-15

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

546233, 546235, 548542, 548950, 548965, A61K 3124, C07C14378

Patent

active

046940200

ABSTRACT:
Derivatives of 2-(substituted sulfamyl) 6-nitrobenzoic acids are disclosed, wherein at least one of the sulfamyl substituents is selected from amino-(lower alkyl), (lower alkyl)-amino-(lower alkyl), or di(lower alkyl)-amino-(lower alkyl), hydrogen, lower alkyl, hydroxy-(lower alkyl), allyl, or when taken together with the nitrogen of the sulfamyl moiety, form a heterocyclic ring. These compounds have activity in increasing the sensitivity of hypoxic tumor cells to therapeutic radiation. Also disclosed are methods of preparing such compounds and pharmaceutical compositions including such compounds.

REFERENCES:
Hamor et al., Chem. Abs. 62 (1965) No. 9, 10362.

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