Derivatives of 2-pyrrolidinone

Details Derivatives of 2-pyrrolidinone Derivatives of 2-pyrrolidinone

1973-11-20

1976-05-11

Gallagher, R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424274, C07D20726

Patent

active

039563146

ABSTRACT:
Phenyl-2-pyrrolidinones of the formula ##SPC1##
Wherein R is a halogen or trifluoromethyl, R.sub.1 is lower alkyl, lower alkenyl, lower alkynyl, phenyl or halogen-substituted phenyl, R.sub.2 is hydrogen, lower alkyl or phenyl and R.sub.3 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, cyclopentyl or benzyl, as well as the cis and trans diastereoisomers thereof, are active on the central nervous system. In particular they have valuable anxiolytic and antidepressive properties. Processes for their preparation are given.

REFERENCES:
patent: 3471548 (1969-10-01), Keberle et al.
patent: 3804854 (1974-04-01), Loev
Strubbe et al., Chem. Abs., Vol. 76:113055j (1972).

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