Derivatives of 2-piperazino-pyrimidine, methods for their prepar

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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544295, 544298, 544326, 544330, 544334, 544335, A61K 31505, C07D40304

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045350809

ABSTRACT:
Compounds are disclosed as useful as drugs or as intermediates for the manufacture of drugs, the compounds having the formula: ##STR1## in which X is hydrogen, chlorine, alkyl, alkoxy or alkylthio having 1 to 3 carbon atoms, R.sub.2 is hydrogen or alkyl having 1 to 3 carbon atoms, Y.sub.2 is chlorine and Y.sub.1 is chlorine or ##STR2## in which R.sub.1 is hydrogen, straight or branched chain alkyl having 1 to 7 carbon atoms, cycloalkyl having 3 to 7 carbon atoms or cycloalkylalkyl having 4 to 8 carbon atoms, or Y.sub.2 and Y.sub.1 are both OH. Also disclosed are methods for preparation of the compounds.

REFERENCES:
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patent: 4051244 (1977-09-01), Mattioda et al.
patent: 4166852 (1979-09-01), Loiseau et al.
Audiau, et al., "Chemical Abstracts", vol. 98, 1983, Col. 98: 89385y.

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