Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-05-23
2006-05-23
Powers, Fiona T. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S657000, C549S075000, C558S394000, C564S428000
Reexamination Certificate
active
07049337
ABSTRACT:
Aminotetralin derivatives and pharmacological analogs thereof which contain an N-propynyl group exhibit differential dopaminergenic receptor activity. The subject compounds are useful in affecting dopamine receptor activity, particularly in exhibiting differing activity among the various dopamine receptor subtypes. The compounds are useful in treating CNS disorders in mammals in general, and humans in particular.
REFERENCES:
patent: 5196454 (1993-03-01), Grauert et al.
patent: 5545755 (1996-08-01), Lin et al.
patent: 5690906 (1997-11-01), Kung
patent: WO-99/62505 (1999-12-01), None
Chumpradit et al., Journal of Medicinal Chemistry, 36(26), 4308-4312, 1993.
Chumpradit et al., Journal of Medicinal Chemistry, 37(24), 4245-4250, 1994.
O. Civelli et al., “Molecular Diversity of the Dopamine Receptors,” Annu. Rev. Pharmacol. Toxicol., 32, 281-307, 1993.
N.E. Austin et al., “Novel 2,3,4,5-Tetrahydro-1H-3-benzazepines with High Affinity and Selectivity for the Dopamine D3Receptor,” Bio. Med. Chem. Ltrs, (2000) 2553-2555.
P. Seeman et al., “Dopamine Receptor Pharmacology,” TIPS, 15, 264-270, 1994.
J.W. Kebabian et al., “Multiple Receptors for Dopamine,” Nature, 277, 93-96, 1979.
S.G. Caine et al., “Modulation of Cocaine Self-Administration in the Rat through D-3 Dopamine Receptors,” Science, 260, 1914-1916, 1993.
S.B. Caine et al., “Pretreatment with the Dopamine Agonist 7-OH-DPAT Shifts the Cocaine Self-Administration Dose Effect Function to the Left Under Different Schedules in the Rat,” Behav. Pharmacol., 6, 33-347, 1995.
H.H.M. Van Tol et al., “Cloning of the Gene for a Human Dopamine D4 Receptor with High Affinity for the Antipsychotic Clozapine,” Nature, 350, 610-614, 1991.
D. Levesque et al., “Identification, Characterization, and Localization of the Dopamine D3 Receptor in Rat Brain Using 7 [3H] hydroxy-N,N-di-n-propyl-2-aminotetralin,” Proc. Natl. Acad. Sci. U.S.A., 89, 8155-8159, 1992.
T.A. Pugsley et al., “Neurochemical and Functional Characterization of the Preferentially Selective Dopamine D3 Agonist PD 128907,” Pharmacol. Exp. Ther., 275, 1355-1366, 1995.
R.G. MacKenzie et al., “Characterization of the Human Dopamine D3 Receptor Expressed in Transfected Cell Lines,” Eur. J. Pharmacol., 266, 79-85, 1994.
P. Sokoloff et al., “Molecular Cloning and Characterization of a Novel Dopamine Receptor (D3) as a Target for Neuroleptics,” Nature, 347, 146, 1990.
J.G. Canon et al, “Centrally Acting Emetics. 6. Derivatives of β-Naphthylamine and 2-Indanamine,” J. Med. Chem., 15, 348-350, 1972.
J.G. Canon et al., “Cerebral Dopamine Agonist Properties of Some 2-Aminotetralin Derivatives after Peripheral and Intracerebral Administration,” J. Med. Chem., 20, 1111-1116, 1977.
J. McDermed et al., “Synthesis and Pharmacology of Some 2-Aminotetralins Dopamine Receptor Agonists,” J. Med. Chem., 18, 362-367, 1975.
J.D. McDermed et al., “Synthesis and Dopaminergic Activity of (+), (+)-, and (−) -2-Dipropylamino-5-hydroxy-1,2,3,4-tetrahydronaphthalene,” J. Med. Chem., 19, 547-549, 1976.
U. Hacksell et al., “N-alkylated 2-Aminotetralins: Central Dopamine-Receptor Stimulating Activity,” J. Med. Chem., 22, 1469-1475, 1979.
L. Alexander Van Vliet et al., “Affinity for Dopamine D2, D3 and D4 Receptors of 2-Aminotetralins. Relevance of D2 Agonist Binding for Determination of Receptor Subtype Selectivity,” J. Med. Chem., 39, 4233-4237, 1996.
M.S. Starr et al., “Motor Actions of 7-OH-DPAT in Normal and Reserpine-Treated Mice Suggest Involvement of Both Dopamine D2 and D3 Receptors,” Eur. J. Pharmacol., 277, 151-158, 1995.
V.J. Watts et al., Eur. J. Pharmacol., 1993, 239, 271.
M.E.A. Reith et al., Biol. Chem., 1986, 261, 7300.
Khroyan et al., “Dose-Dependent Effects of the D3—preferring agonist 8-OH-DPAT on Motor Behaviors and Place Conditioning,” Psychopharmacol. 122:351-57 (1995).
Brooks & Kushman P.C.
Powers Fiona T.
Wayne State University
LandOfFree
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