Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Patent
1980-01-23
1982-02-02
Hines, Robert V.
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
26050118, 424316, 424330, 560138, 560142, C07C 8728
Patent
active
043140823
ABSTRACT:
This invention provides derivatives of 2-Amino-6,7-dihydroxy-tetrahydronaphthalene (ADTN) represented by the formula ##STR1## wherein R is OH, alkyloxy, hydroxyalkyl or acyloxy, and R' is an arylalkyl where the aryl group is benzyl, substituted benzyl, phenyl or substituted phenyl and the alkyl group is a straight or branched chain alkyl having one to twenty carbon atoms; and the pharmaceutically acceptable salts thereof.
These derivatives of 2-Amino-6,7-dihydroxytetrahydronaphthalene are useful as inotropes.
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patent: 3579582 (1971-05-01), Symon
patent: 3930022 (1975-12-01), Hauck et al.
patent: 4163063 (1979-07-01), Cannon et al.
McDermed et al. "Journal of Medical Chemistry" vol. 18, No. 4, pp. 362-367 (1975).
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Burger, "Medicinal Chemistry", 2nd Ed. pp. 596-597 (1960).
Cannon et al. "Journal Medicinal Chemistry", vol. 20, pp. 1111-1116 (1977).
American Hospital Supply Corporation
Hines Robert V.
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