Derivatives of 2-amino-1-phenylethanol having antiulcer activity

Details Derivatives of 2-amino-1-phenylethanol having antiulcer activity Derivatives of 2-amino-1-phenylethanol having antiulcer activity

1991-05-15

1992-12-15

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514255, 514651, 514926, 514927, 544401, 564346, 564363, 564364, 564365, A61K 31135, A61K 31495, C07C21534, C07D29513

Patent

active

051717530

ABSTRACT:
Derivatives of 2-amino-1-phenylethanol were prepared from substituted amines and benzoin, stilbene oxide or styrene oxide to give compounds of Formula: ##STR1## where R is H or (un)substituted phenyl and C is a linking group or terminal group. The compounds of this invention can inhibit ulceration in in-vivo studies in rats.

REFERENCES:
patent: 2884459 (1959-04-01), Kirkpatrick, II
patent: 3152188 (1964-10-01), Kirkpatrick, I
patent: 3928621 (1975-12-01), Boris
patent: 4618624 (1986-10-01), Asato
patent: 4723039 (1988-02-01), Seitz et al.
patent: 4803200 (1989-02-01), Munson, Jr. et al.
J. Amer. Chem. Soc., 70, 2015-2023 (1948).
J. Amer. Chem. Soc., 71, 478-481 (1949).

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