Derivatives of 2,4-thiazolidinedione

Details Derivatives of 2,4-thiazolidinedione Derivatives of 2,4-thiazolidinedione

1986-10-09

1987-09-29

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548182, 548183, C07D23328, A61K 31425

Patent

active

046970207

ABSTRACT:
Compounds of the class of 2,2'-azines of 2,4-thiazolidinediones which are substituted in at least one of the 3-positions by allyl, 1-methylallyl, 2-methylallyl or 2-propynyl and in at least one of the 5-positions by hydroxy, and may further contain methyl groups in the remaining 3-position and in the 5-positions, and the corresponding tautomeric 1-[[4-oxo-2-thiazolidinylidene]amino]-5-hydroxy-2-thiohydantoins and 5,5'-dihydroxy-2,2'-dithio-1,1'-bihydantoins have valuable pharmacological properties. In particular, they inhibit the growth of tumours, while their toxicity is low in comparison with their tumour-inhibiting effectiveness. A specific embodiment is the 2,2'-azine of 3-(2-methylallyl)-5-methyl-2,4-thiazolidinedione and of 3-methyl-5-hydroxy-2,4-thiazolidinedione.

REFERENCES:
patent: 3699116 (1972-10-01), Meisels

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