Derivatives of 2,3,4,5,6,7-hexahydro-2,7-methano-1,5-benzoxazoni

Details Derivatives of 2,3,4,5,6,7-hexahydro-2,7-methano-1,5-benzoxazoni Derivatives of 2,3,4,5,6,7-hexahydro-2,7-methano-1,5-benzoxazoni

1987-09-04

1989-08-22

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514454, 540581, 549386, C07D26700, A61K 3133

Patent

active

048596647

ABSTRACT:
New 2,3,4,5,6,7-hexahydro-2,7-methano-1,5-benzoxazonine and -1,4-benzoxazonine compounds of the formula ##STR1## have useful pharmaceutical properites. They are prepared from ketones of the formula ##STR2## via a lactone intermediate. In the formula, the various R substitutes are generally hydrogen or alkyl, with R.sup.4 also being halogen or alkoxy and R.sup.3 R.sup.3' also being phenyl. R.sup.1 may be joined with R.sup.5 /R.sup.5' in a 5- to 7-membered ring possibly interrupted by O, S, SO.sub.2 or amino. One of X and Y is CH.sub.2 ; the other is amino. The starting ketones also have pharmaceutical properties. The lactone intermediates are new compounds.

REFERENCES:
patent: 3441564 (1969-04-01), Krapcho et al.
patent: 3446820 (1969-05-01), Klohs et al.
patent: 4100277 (1978-07-01), Demerson et al.

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