Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2008-09-02
2008-09-02
Kifle, Bruck (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S238000
Reexamination Certificate
active
10584473
ABSTRACT:
The invention relates to heterocyclic derivatives of formula (I), wherein R2is amino, a group OR4or a group —Y—R5where R4is hydrogen or C1-4alkyl, Y is C1-4alkylene, R5is hydrogen, halo, hydroxy, C1-2alkoxy, C1-2alkoxyC1-2alkoxyC1-4, or a group NR7R8where R7and R8are independently selected from hydrogen, C1-2alkyl, hydroxyC1-2alkyl or alkoxyC1-2alkyl, or R7and R8together with the nitrogen atom to which they are attached form a saturated 5-6-membered heterocyclic ring which optionally contains an additional heteroatom; n is one or two and each R1is independently selected from halo, haloC1-2alkyl, hydroxy, oxo, amino, C1-2alkylamino or di-C1-2dialkylamino; or a pharmaceutically acceptable salt thereof. These compounds possess antithrombotic and anticoagulant properties and are accordingly useful in methods of treatment of humans or animals. The invention also relates to processes for the preparation of the heterocyclic derivatives, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments for use in the production of an antithrombotic or anticoagulant effect.
REFERENCES:
patent: 6395731 (2002-05-01), Thorsten et al.
patent: 1104754 (2001-06-01), None
patent: WO 9957099 (1999-11-01), None
patent: WO 9957113 (1999-11-01), None
Bratt Emma
Chen Yantao
Granberg Kenneth
Nilsson Ingemar
AstraZeneca AB
Kifle Bruck
Morgan & Lewis & Bockius, LLP
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