Derivatives of 12,13-Epoxy-tylosin and processes of manufacture

Details Derivatives of 12,13-Epoxy-tylosin and processes of manufacture Derivatives of 12,13-Epoxy-tylosin and processes of manufacture

1996-08-13

1997-11-18

Dentz, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

549270, C07D31300, C07H 506, C07H 1708

Patent

active

056889240

ABSTRACT:
The invention relates to derivatives of 12,13-epoxy-tylosin, the novel seynthetic antibiotics from tylosin group and the methods of their preparation. According to this invention hydrogenation followed by oximation of 12,13-epoxy-tylosin derivatives yields the following tylosin derivatives: 10,11-dihydro-12,13-epoxy, respectively 10,11-dihydro-12,13-epoxy oxime.
Direct oximation of 12,13-epoxy tylosin derivative gives 12,13-epoxy oxime derivatives of tylosin.

REFERENCES:
patent: 4808575 (1989-02-01), Mallams et al.

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