Derivatives of 10-nitro-7-oxo-7H-indolizino[7,6,5-de]isoquinolin

Details Derivatives of 10-nitro-7-oxo-7H-indolizino[7,6,5-de]isoquinolin Derivatives of 10-nitro-7-oxo-7H-indolizino[7,6,5-de]isoquinolin

1977-06-14

1979-01-30

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424250, 424258, 424262, 544 58, 544125, 544361, 546 66, 546 48, 546141, C07D47114, A61K 31475

Patent

active

041373154

ABSTRACT:
Indolizino[7,6,5-de]isoquinoline derivatives of the general formula: ##STR1## wherein the symbol R.sub.1 represents a hydrogen atom, the symbol R.sub.2 represents a hydrogen atom, an amino radical, or a straight- or branched-chain alkyl radical which is optionally substituted on a terminal carbon atom by a vinyl, ethynyl, carboxy, alkoxycarbonyl, cyano, dialkoxymethyl, hydroxymethyl, dialkylaminomethyl (the alkyl radicals of which may form with the nitrogen atom to which they are attached a saturated five- or six-membered heterocyclic ring which may contain another hetero-atom selected from nitrogen, oxygen and sulphur, and -- when a second nitrogen atom is present -- may optionally be N-methylated) or trialkylammoniomethyl radical, or R.sub.2 represents a straight- chain alkyl radical which is substituted on the terminal carbon atom by an aminomethyl, alkylaminomethyl or hydroxyalkylaminomethyl radical, and the symbols R.sub.3 and R.sub.4 together form a valence bond, or the symbols R.sub.1 and R.sub.4 together form a valence bond and the symbols R.sub.2 and R.sub.3 together form a grouping of the general formula: ##STR2## wherein the group --OR.sub.5, which represents an alkoxy radical, is attached to the carbon atom situated in the .alpha.-position to the nitrogen atom carrying R.sub.3, the alkyl and alkoxy radicals, or moieties of groups, within the definition of symbols R.sub.2 and R.sub.5 containing from 1 to 4 carbon atoms and their salts are active as antimicrobial agents and antifungal agents, and are suitable for use as local antiseptics.

REFERENCES:
patent: 4053300 (1977-10-01), Farge et al.

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