Derivatives of 1-phenoxy-3-amino-propane-2-ol and process for th

Details Derivatives of 1-phenoxy-3-amino-propane-2-ol and process for th Derivatives of 1-phenoxy-3-amino-propane-2-ol and process for th

1974-07-12

1977-04-19

Randolph, John D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424263, 260240J, 2602948R, 260295AM, 2602955A, 260297R, 260307F, 260348R, 2605705C, 260590C, 260590D, 260590E, 260590R, C07D21328

Patent

active

040187780

ABSTRACT:
The present invention relates to pharmacologically valuable new derivatives of 1-phenoxy-3-amino-propane-2-ol and process for their production. The new derivatives of 1-phenoxy-3-amino-propane-2-ol are suitable for the treatment and prophylaxis of diseases of the heart. Some possess pronounced .beta.-adrenalytic or anti-arythmic properties. These new derivatives have the structural formula ##STR1## wherein X signifies ##STR2## and the phenyl nucleus I may be mono-, di- or trisubstituted by alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, alkoxy, alkenyloxy, phenyl, halogen or the radical --NR.sub.1 R.sub.2, in which R.sub.1 stands for alkyl or acyl and R.sub.2 for hydrogen or alkyl, together with their aldehyde condensation products and their acid addition salts.

REFERENCES:
patent: 3328417 (1967-06-01), McLoughlin et al.
patent: 3412154 (1968-11-01), Fleming et al.
patent: 3679693 (1972-07-01), Ross et al.
patent: 3723476 (1973-03-01), Nakanishi et al.
patent: 3830806 (1974-08-01), Raabe et al.
patent: 3862953 (1975-01-01), Berger et al.

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