Derivatives of 1-phenoxy-3-amino-propan-2-ol and process for the

Details Derivatives of 1-phenoxy-3-amino-propan-2-ol and process for the Derivatives of 1-phenoxy-3-amino-propan-2-ol and process for the

1974-12-10

1976-07-13

Randolph, John D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424263, 260240J, 260296R, 260307F, 260348R, 2605705C, C07D21372

Patent

active

039693635

ABSTRACT:
The present invention relates to new pharmacologically valuable derivatives of 1-phenoxy-3-amino-propan-2-ol having the formula ##EQU1## and the aldehyde condensation products and acid addition salts thereof wherein X is selected from the group consisting of ##EQU2## wherein the phenyl ring I may have attached to it up to three similar or different substituents selected from the group consisting of alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, alkoxy, alkenyloxy, alkinyloxy, benzyloxy, phenyl, halogen and --NR.sub.1 R.sub.2, wherein R.sub.1 is selected from alkyl and acyl, and R.sub.2 is selected from hydrogen and alkyl and n is 1, 2 or 3; and to the production thereof by a method selected from (A) reacting 1-phenoxy-3-amino-propan-2-ol having the formula ##EQU3## with a compound having the formula Y-X, wherein X has the above defined meaning and Y is selected from halogen, --OH, --OK or --ONa; (B) reacting a compound of the formula ##EQU4## with a compound of the formula H.sub.2 N--X, wherein X has the above-defined meaning and Z is selected from ##EQU5## and ##EQU6## (C) reacting a phenol ##EQU7## with Z--CH.sub.2 --NH--X, wherein X and Z have the meaning defined above.

REFERENCES:
patent: 3328417 (1967-06-01), McLoughlin et al.
patent: 3412154 (1968-11-01), Fleming et al.
patent: 3679693 (1972-07-01), Ross et al.
patent: 3723476 (1973-03-01), Nakanishi et al.
patent: 3830806 (1974-08-01), Raabe et al.
patent: 3862953 (1975-01-01), Berger et al.

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