Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1976-03-24
1978-01-03
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
542424, 260295D, 260295S, 260296AE, 2602564R, A61K 3144, C07D21336
Patent
active
040667685
ABSTRACT:
The present invention relates to new pharmacologically valuable derivatives of 1-phenoxy-3-amino-propan-2-ol having the formula ##STR1## wherein X denotes ##STR2## A denotes --CH.sub.2 --alkoxy, --O--alkoxyalkyl, --O--hydroxyalkyl or ##STR3## AN AROMATIC OR QUASI-AROMATIC, 5-MEMBERED OR 6-MEMBERED, MONOCYCLIC RING WHICH IS LINKED THROUGH A C atom which has one or 2 nitrogen, oxygen and/or sulphur hetero-atoms and which can be substituted additionally by one or more methyl groups, and R.sub.2 and R.sub.3 denote hydrogen, alkyl, alkenyl or cycloalkyl or, conjointly with the N atom to which they are linked, and optionally with a further oxygen or sulphur hetero-atom, denote a saturated, 5-membered or 6-membered, monocyclic, heterocyclic structure, and alkyl radicals contain 1 to 4 carbon atoms, alkoxy radicals contain 1 to 4 carbon atoms, alkenyl radicals contain 3 to 4 carbon atoms and cycloalkyl radicals contain 5 to 7 carbon atoms; and aldehyde condensation products and acid addition salts thereof and to the production thereof by a method selected from (A) reacting a compound having the formula ##STR4## with a compound of the general formula Y -- X wherein X has the meanings indicated above and Y represents halogen and, if X denotes ##STR5## ALSO REPRESENTS --OH, --OK and --ONa; (B) reacting a compound having the formula ##STR6## with a compound of the formula H.sub.2 N--X wherein X has the meanings indicated above and Z represents ##STR7## AND Hal denotes halogen; (C) reacting a phenol of the formula ##STR8## with a compound of the formula Z--CH.sub.2 NH--X wherein X has the meanings indicated above and Z denotes ##STR9## WHEREIN Hal represents a halogen atom; and that the resulting compound is optionally reacted with an aldehyde of the formula R.sub.4 --CHO, wherein R.sub.4 denotes hydrogen or a lower alkyl radical having up to 4 C atoms, to form an oxyzolidine of the formula ##STR10## or is optionally reacted with an acid to form an acid addition salt.
REFERENCES:
patent: 3830806 (1974-08-01), Raabe et al.
patent: 3852291 (1974-12-01), Augstein et al.
patent: 3940406 (1976-02-01), Raabe et al.
patent: 3969363 (1976-07-01), Raabe et al.
Grawinger Otto
Nitz Rolf-Eberhard
Raabe Thomas
Scholtholt Josef
Schraven Eckhard
Cassella Farbwerke Mainkur Aktiengesellschaft
Rotman Alan L.
LandOfFree
Derivatives of 1-phenoxy-3-amino-propan-2-ol does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Derivatives of 1-phenoxy-3-amino-propan-2-ol, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Derivatives of 1-phenoxy-3-amino-propan-2-ol will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-281543