Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2003-04-01
2008-07-22
McKane, Joseph K. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S423000, C514S414000, C514S406000, C514S378000, C514S367000, C514S365000, C514S361000, C514S364000, C514S363000, C514S314000, C514S343000, C514S255050, C514S235500, C544S141000, C544S405000, C546S278400, C546S168000, C546S270400, C548S544000, C548S556000, C548S525000, C548S127000, C548S236000, C548S255000, C548S261000, C548S468000, C548S248000, C548S266800, C548S362500, C548S247000, C548S203000, C548S131000, C548S162000, C549S475000
Reexamination Certificate
active
07402606
ABSTRACT:
Heterocycle substituted ketoamide derivatives of Formula (I), wherein the substitutes A, D, A and R are defined as in claim in, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such heterocycle substituted ketoamide derivatives as well as method of using the same in the manufacture of medicaments for the treatment of disorders, including osteoporosis, associated with an imbalance between bone resorption and formation which can ultimately lead to fracture.
REFERENCES:
patent: 1 008 592 (2000-06-01), None
patent: 96/16079 (1996-05-01), None
patent: 03/013518 (2003-02-01), None
patent: 03/062192 (2003-07-01), None
Morissette et al. Advanced Drug Delivery Reviews 2004, 56, 275-300.
Barrett David Gene
Catalano John G.
Deaton David Norman
Miller Aaron Bayne
Ray John A.
Coulter Kathryn L.
Lemanowicz John L.
McKane Joseph K.
Nolan Jason M
SmithKline Beecham Corporation
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