Derivatives of 1,4-dideoxy-1,4-imino-D-mannitol and a process fo

Details Derivatives of 1,4-dideoxy-1,4-imino-D-mannitol and a process fo Derivatives of 1,4-dideoxy-1,4-imino-D-mannitol and a process fo

1990-01-08

1991-02-26

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548541, C07D20712

Patent

active

049963295

ABSTRACT:
Novel derivatives of 1,4-dideoxy-1,4-imino-D-mannitol and method for their synthesis from 4,5-anhydro-1-azido-1-deoxy-2,3-O-isopropylidene-D-talitol or its triflate derivative are disclosed. The novel derivatives, 6-fluoro-1,4-imino-1,4,6-trideoxy-D-mannitol and the N-butyl and N-benzyl derivatives of 1,4-dideoxy-1,4-amino-D-mannitol, have useful mannosidase inhibitory activity.

REFERENCES:
Fleet, J. Chem. Soc. Chem. Commun. 1984, pp. 1240-1241.
Bashyal et al., Tetrahedron 43, 3083-3093, (1987).
Fleet et al., FEBS Lett. 237, 128-132, (1988).

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