Derivatives of 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine

Details Derivatives of 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine Derivatives of 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine

1974-07-22

1978-02-28

Killos, Paul J.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D21106

Patent

active

040767175

ABSTRACT:
The subject compounds are ester, thioester, amide, hydrazide and anhydride derivatives of 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylic acid. These compounds are prepared by reacting the aforementioned acid with the appropriate alcohol, thiol, amine, or the like in the presence of a suitable dehydrating agent, or by reacting the acid chloride derivative of the aforementioned acid with the appropriate alcohol, thiol, amine or the like. A further embodiment of this invention is N-oxide derivative of 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylic acid. This N-oxide compound is prepared by peracid treatment of the mentioned acid. The instant compounds share various valuable pharmacological properties, including analgesic and especially potent antidiarrheal properties.

REFERENCES:
patent: 3539579 (1970-11-01), Janssen

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