Derivatives of 1,2-dithiole and anti-bilharzia compositions ther

Details Derivatives of 1,2-dithiole and anti-bilharzia compositions ther Derivatives of 1,2-dithiole and anti-bilharzia compositions ther

1977-02-09

1978-08-01

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424251, 544238, 544333, A61K 3150, A61K 31505, C07D40904

Patent

active

041043863

ABSTRACT:
1,2-Dithiole derivatives of the formula: ##STR1## wherein Het represents a pyridazin-3-yl radical, or a pyrimidin-2-yl, -4-yl or -5-yl radical, each such radical being optionally substituted by a halogen atom or by an alkyl radical of 1 through 4 carbon atoms, an alkoxy radical of 1 through 4 carbon atoms, the mercapto radical, an alkylthio radical of 1 through 4 carbon atoms or a dialkylamino group having 1 through 4 carbon atoms in each alkyl radical, are new compounds useful in the treatment of bilharziasis and amoebiases.

REFERENCES:
patent: 3791789 (1974-02-01), Alink
patent: 3957925 (1976-05-01), Alink
Bottcher et al., Chem. Ber 84, 458-463 (1951).
Legrand et al., Bull. Soc. Chim. (France), pp. 79-83 (1955).
Chemistry of Heterocyclic Compound, vol. 21, pt. 1, pp. 382-384 (1966).

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