Derivatives of 1-(2-,3- or 4-quinolyl)-2- or -3-(2- or 3-piperid

Details Derivatives of 1-(2-,3- or 4-quinolyl)-2- or -3-(2- or 3-piperid Derivatives of 1-(2-,3- or 4-quinolyl)-2- or -3-(2- or 3-piperid

1981-06-09

1983-09-06

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546167, 546168, 546173, 546176, A61K 3147, C07D40106

Patent

active

044029616

ABSTRACT:
Compounds, useful as medicaments, of the formula: ##STR1## in which R is fixed in position 2 or 4 on the cycle of the quinoline and indicates a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, pyridyl, thienyl, phenyl or substituted phenyl group, X is fixed in position 5, 6, 7 or 8 on the cycle of the quinoline and indicates a hydrogen or halogen atom or an alkyl, alkoxy or alkylthio group containing 1 to 4 carbon atoms or CF.sub.3 group, R.sub.1 is a hydrogen atom or an alkyl containing 1 to 4 carbon atoms, alkenyl containing 3 to 4 carbon atoms or arylalkyl group, A is a CO, CHOH, or CH.sub.2 group, n and p are equal to 1 or 2, the group ##STR2## is fixed in position 2, 3 or 4 on the cycle of the quinoline and the group ##STR3## is fixed in position 2 or 3 on the nitrogen heterocycle ##STR4##

REFERENCES:
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patent: 3857837 (1974-12-01), Gutzwiller et al.
patent: 3953453 (1976-04-01), Grethe et al.
patent: 4237139 (1980-12-01), Champseix et al.
patent: 4238612 (1980-12-01), Barieux et al.
patent: 4299835 (1981-11-01), Champseix et al.
Heidelberger et al., J. Am. Chem. Soc., vol. 44, pp. 1098-1107 (1922).
Wirth Chemical Abstracts, vol. 76, 103,776f (1972).
Wirth, Chemical Abstracts, vol. 80, 124,762w (1974).
Gutzwiller et al., J. Am. Chem. Soc., vol. 100, No. 2, pp. 576-581, 1978.
Grethe, Chemical Abstracts, vol. 83, 114,718j (1975).
Wagner et al., "Synthetic Organic Chemistry", p. 5, J. Wiley & Sons (1953).
"Organic Reactions", vol. 5, p. 301, John Wiley & Sons (1949).

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