Derivatives of 1,1,2,2-tetramethyl-1,2-bis-(2-fluoro-4-hydroxyph

Details Derivatives of 1,1,2,2-tetramethyl-1,2-bis-(2-fluoro-4-hydroxyph Derivatives of 1,1,2,2-tetramethyl-1,2-bis-(2-fluoro-4-hydroxyph

1986-06-09

1988-05-17

Lone, Werren B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

514483, 514490, 514548, 514549, 514550, 558 62, 560133, 560138, 568726, C07C 3914, C07C12504, C07C12506

Patent

active

047452331

ABSTRACT:
Antitumor compounds corresponding to the following formula: ##STR1## in which the substituents R.sub.1 and R.sub.2 may be the same or different and represent hydrogen, an aminocarbonyl group, a C.sub.1 -C.sub.6 alkylaminocarbonyl group, a di-C.sub.1 -C.sub.6 -alkylaminocarbonyl group, the group PO(OH).sub.2, a C.sub.2 -C.sub.8 alkanoyl group, a C.sub.2 -C.sub.8 halogen alkanoyl group or a C.sub.3 -C.sub.8 alkenoyl group, a process for their preparation, and their use in treating oestrogen-receptor-positive-tumors as well as the prostate carcinoma.

REFERENCES:
patent: 4427697 (1984-01-01), Chan
patent: 4467121 (1984-08-01), Marks et al.

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