Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2011-03-22
2011-03-22
Saeed, Kamal A (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S060000
Reexamination Certificate
active
07910581
ABSTRACT:
The present invention concerns pyrrole compounds, derivatives of 1-{[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl}-4-methylpiperazine (BM212). The invention concerns the use of the described compounds as antitubercular agents having high activity and low toxicity and process to obtain intermediates and final compounds.
REFERENCES:
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patent: 3819037 (1989-12-01), None
patent: 62-178590 (1987-08-01), None
Patani et al., Bioisosterism: A Rational Approach in Drug Design, 1996, Chem. Rev., 96, 3147-3176.
Biava et al., “Antimycobacterial compounds. Optimization of the BM 212 structure, the lead compound . . . ,”Bioorganic & Medicinal Chemestry,vol. 13,pp. 1221-1230(Elsevier Ltd 2005).
Wermuth, “Molecular variations based on isosteric replacements,” The Practice of Medicinal Chemistry, pp. 203-237 (Academic Press Limited 1996).
Biava Mariangela
Botta Maurizio
Deidda Delia
Manetti Fabrizio
Pompei Raffaello
Bianchi Kristin
Lucas & Mercanti LLP
Saeed Kamal A
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