Derivatives and preparation of 2,2-dimethyl-5-substituted phenox

Details Derivatives and preparation of 2,2-dimethyl-5-substituted phenox Derivatives and preparation of 2,2-dimethyl-5-substituted phenox

1994-06-14

1995-05-02

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549329, 560 61, 560 60, 562470, 562471, C07D30512, C07C 6976, C07C 5948

Patent

active

054121124

ABSTRACT:
Novel 3-substituted derivatives of 2,2-dimethyl-5-substituted phenoxy-pentanoic acids of formula (I) are prepared. These compouds are prepared from 2,2-dimethyl-5-substituted phenoxy-3-hydroxy-pentanoic acid-.beta.-lactones (formula II). The .beta.-lactones are prepared by condensing relevant phenoxypropanals with dimethylketene.

REFERENCES:
patent: 3344168 (1967-09-01), Galimberti
patent: 3474095 (1969-10-01), Marchetti
patent: 3674836 (1972-07-01), Creger
patent: 3707566 (1972-12-01), Creger et al.
patent: 4665226 (1987-05-01), Kearney
patent: 4739101 (1988-04-01), Bourgogne
patent: 5302751 (1994-04-01), Marimaran
patent: 5310757 (1994-05-01), Laruelle
Morishita et al., "Synthesis and Hypolipidemic Activity of 2-Substituted Isobutyric Acid Derivatives", J. Med. Chem. 31:1205-1209, (1988).
Sircar et al., "Phenylenebis(oxy)bis[2,2-dimethylpentanoic acid]s: Agents that Elevate High.varies.Density Lipoproteins", J. Med. Chem. 26:1020-1027, (1983).

Affiliated with

Also associated with

Rating

Derivatives and preparation of 2,2-dimethyl-5-substituted phenox does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Derivatives and preparation of 2,2-dimethyl-5-substituted phenox, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Derivatives and preparation of 2,2-dimethyl-5-substituted phenox will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1138418