Derivatives and precursors of captopril and its analogues

Details Derivatives and precursors of captopril and its analogues Derivatives and precursors of captopril and its analogues

1991-03-05

1993-08-17

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548519, C07D40312

Patent

active

052370739

ABSTRACT:
This invention relates to novel S-protected derivatives of an orally active inhibitor of an angiotensin-converting enzyme (ACE) and its analogues, which derivatives are useful for the reasons that they are (1) easily prepared from novel precursors, (2) resolvable to their optically purified stereoisomeric species and (3) convertible to non-derivatized stereoisomeric species which correspond to the pharmacologically active inhibitor and its analogues. Consequently, this invention also relates to the novel precursors. Novel methods for preparing the derivatives and their precursors are also noted herein. In addition, methods for converting the derivatives to the resolved de-derivatized stereoisomeric species of the ACE inhibitor and its analogues are described.

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Chemical Abstracts, vol. 87, Abstract No. 52725f (1977), Mustafaev, et al.
Wilen et al., Tetrahedron, vol. 33: pp. 2725-2736 (1977).

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