Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Reexamination Certificate
2005-11-01
2005-11-01
Kumar, Shailendra (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
C514S624000
Reexamination Certificate
active
06960687
ABSTRACT:
New derivatives of N-Hydroxyalkyl-tetramethylcyclopropane carboxamide, pharmaceutical compositions thereof, methods for their preparation, and use thereof for the treatment of epilepsy, neurological, affective and psychotic disorders and for the treatment of pain and migraine.
REFERENCES:
patent: 5880157 (1999-03-01), Sterling et al.
patent: 6417399 (2002-07-01), Bialer et al.
patent: 6630602 (2003-10-01), Bialer et al.
patent: 2002/0115718 (2002-08-01), Chen et al.
patent: WO 95/09835 (1995-04-01), None
patent: WO 95/21814 (1995-08-01), None
patent: WO 98/30538 (1998-07-01), None
patent: WO 99/48859 (1999-09-01), None
patent: WO 99/54282 (1999-10-01), None
patent: WO 02/46188 (2002-08-01), None
Bialer, Meir et al “Pharmacokinetic Analysis and Antiepileptic Activity of Tetra-Methylcyclopropane Analogues of Valpromide” Pharmaceutical Research (1996) vol. 13, No. 2, pp: 284-189.
Bialer M “Pharmacokinetic considerations in the design of better and safer new antiepileptic drugs” Journal of Controlled Release, Elsevier Science Publishers B.V. Amsterdam, NL, (Nov. 1, 1999) vol. 62, co. 1-2 pp:187-192.
Bialer M et al “Pharmacokinetics of a Valpromide Isomer. Valnoctamide, in Healthy Subjects” European Journal of Clinical Pharmacology, Springer Verlag, DE (1990) vol. 38, No. 3. pp:289-291, XP002063380 ISSN: 0031-6970 ★p. 289★.
Database BIOSIS ‘Online!’ Biosciences Information Service, retrieved from MEDLINE Database accession No. prev199698701231 XP002235669 abstract & Bialer Meir et al “Pharmacocinetic analysis and antiepileptic activity of tetra-methylcyclopropane analogues of valpromide” Pharmaceutical Research (1996) vol. 13, No. 2, pp: 284-289.
Database BIOSIS ‘Online!’ Biosciences Information Service, retrieved from MEDLINE Database accession No. prev199799414598 XP002235672 abstract Malhotra Jatinder et al “Effect of adenosine receptor modulation on pentylenetetrazole—induced seizures in rates” British Journal of Pharmacology (1997) vol. 120, No. 2, pp. 282-288.
Database BIOSIS ‘Online!’ Biosciences Information Service, retrieved from MEDLINE Database accession No. prev199800261866 XP002235673 abstract & Blotnik Simcha et al“Disposition of two tetramethylcyclopropane analogues of valpromide in the brain, liver, plasma and urine of rats” European Journal of Pharmaceutical Sciences (1998) vol. 6, No. 2, pp: 93-98.
Database BIOSIS ‘Online!’ Biosciences Information Service, retrieved from MEDLINE Database accession No. prev200200550317 XP002235671 abstract & Huber Alexander, Guttinger Martin et al: “Seizure suppression by adenosine A2A receptor activation in a rat model of audiogenic brainstem epilepsy” Neuroscience Letters, vol. 329, No. 3, (Sep. 6, 2002) pp:289-292.
Database BIOSIS ‘Online!’ Chemical Abstracts Service, retrieved from Registry Database accession No. 1975:478893 XP002235674 abstract & ZA 7 400 202 A (Hexachimie S.A., FR) (Nov. 27, 1974.
Greenberg M.L. et al “Inhibition of myo-inositol-phosphate synthase by valproate: a mechanism for mood stabilization ”European Neuropsychopharmacology (2003) vol. 13 (Supplement 4) pp: S107-S108.
Isoherranen Nina et al “Anticonvulsant profile and teratogenicity of N-methylcyclopropyl carboxamide: A new antiepileptic drug” Epilepsia (2002) vol. 43, No. 2, pp: 115-126.
Isoherranen Nina et al “New CNS-active drugs which are second-generation valproic acid: can they lead to the development of a magic bullet?” Current Opinion in Neurology (2003) vol. 16, pp:203-211.
Jinming Gao et al “Increasing Binding Constants of Ligands to Carbonic Anhydrase by Using Greasy Tails” J. Med. Chem. (1995) vol. 38, pp:2292-2301.
Shamir Agam G. et al “Myo-inositol-1-phosphate (MIP) synthase: a possible new target for antibipolar drugs” Bipolar Disorders (2002) vol. 4 (Supple. 1) pp:15-20.
Shuto S et al “Synthesis and Biological Activity of Conformationally Restricted Analogs of Milnacipran:(1S,2R)-1-Phenyl-2-U(S)-1-Aminopropyl)-N,N-DI Ethylcyclopropanecarboxamide, and Efficient Noncompetitive N-Methyl-D-Aspartic Acid Recepto Antagonist” Journal of Medicinal Chemistry, American Chemical Society (Nov. 22, 1996) vol. 39, No. 24, pp:4844-4852.
Shuto S et al “(Plus or Minus)-(Z)-2-(Aminomethyl)-1-Phenylcyclopropanecarboximide Derivatives as a New Prototype of NMDA Receptor Antagonists” Journal of Medicinal Chemistry, American Chemical Society (Jul. 21, 1995) vol. 38, No. 15, pp:2964-2968.
Spiegelstein O et al “Enantioselective Synthesis and Teratogenicity of Propylisopropyl Acetamide, a CNS-Active Chiral Amide Analogue of Valproic Acid” Chirality (1999) vol. 1, pp:645-650.
Bialer Meir
Isoherranen Nina
Yagen Boris
Browdy and Neimark PLLC
Kumar Shailendra
Yissum Research Development Company of the Hebrew University of
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