Derivatives and anologs of monoethylglycinexylidide

Details Derivatives and anologs of monoethylglycinexylidide Derivatives and anologs of monoethylglycinexylidide

1992-01-14

1994-06-07

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D49310

Patent

active

053191056

ABSTRACT:
A substituted monoethylglycinexylidide or analogue is disclosed. The xylidide or analogue has the structure of FIG. 1 of the attached drawings where M is CH.sub.2 NHCH.sub.2 CH.sub.3, CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 or CH.sub.2 OCH.sub.2 CH.sub.3, one of Y.sup.1 and Y.sup.2 is H and the other is a protein or a fluorescein moiety chemically bonded to the glycinexylidide or analogue moiety. Also disclosed is a method for carrying out immunoassays for MEGX, which has the structure of FIG. 3 of the attached drawings. The method for carrying out immunoassays involves using the foregoing compounds as tracers and immunogens.

REFERENCES:
patent: 4510251 (1985-04-01), Kirkemo et al.
patent: 4593089 (1986-06-01), Wang et al.
patent: 4614823 (1986-09-01), Kirkemo et al.
patent: 4668640 (1987-05-01), Wang et al.
patent: 5099000 (1992-03-01), Kolaczkowski et al.
J. Clin. Chem. Clin. Biochem. vol. 25, 1987, pp. 845-853 "Monoethylglycinexylidide Formation Kinetics: A Novel Approach to Assessment of Liver Function".

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