Derivatives and analogues of monoethylglycinexylidide and their

Details Derivatives and analogues of monoethylglycinexylidide and their Derivatives and analogues of monoethylglycinexylidide and their

1989-12-22

1992-03-24

Russel, Jeffrey E.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Albumin

530404, 530405, 530406, 530408, 530409, 436544, 436546, C07K 1702, G01N 3353, G01N 33533

Patent

active

050990004

ABSTRACT:
A substituted monoethylglycinexylidide or analogue is disclosed. The xylidide or analogue has the structure of FIG. 1 of the attached drawings where M is CH.sub.2 NHCH.sub.2 CH.sub.3, CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 or CH.sub.2 OCH.sub.2 CH.sub.3, one of Y.sup.1 and Y.sup.2 is H and the other is a protein or a fluorescein moiety chemcially bonded to the glycinexylidide or analogue moiety. Also disclosed is a method for carrying out immunoassays for MEGX, which has the structure of FIG. 3 of the attached drawings. The method for carrying out immunoassays involves using the foregoing compounds as tracers and immunogens.

REFERENCES:
patent: 4058511 (1977-11-01), Singh
patent: 4069105 (1978-01-01), Singh
patent: 4510251 (1985-04-01), Kirkemo et al.
patent: 4593089 (1986-06-01), Wang et al.
patent: 4650771 (1987-03-01), Buckler et al.
Blair et al. (1983) J. Immunol. Methods 59 129-143.
J. Clin. Chem. Clin. Biochem., vol. 25, 1987, pp. 845-853 "Monoethylglycinexylidide Formation Kinetics: A Novel Approach to Assessment of Liver Function.sup.1)", Oellerich et al.

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