Derivatives and analogues of 2-deoxy-2,3-didehydro-n-acetyl neur

Details Derivatives and analogues of 2-deoxy-2,3-didehydro-n-acetyl neur Derivatives and analogues of 2-deoxy-2,3-didehydro-n-acetyl neur

1994-10-19

1997-07-15

Killos, Paul J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549 13, 549 28, 549417, 549419, 549420, 549423, 549424, 514460, C07C30920

Patent

active

056483791

ABSTRACT:
Derivatives and analogues of 2-deoxy-2,3-didehydro-N-acetyl neuraminic acid, pharmaceutical formulations thereof, methods for their preparation and their use in the treatment of viral infections, in particular influenza, are described.

REFERENCES:
Schreiner et al., "Synthesis Of Some 2,3-didehydro-2-deoxysialic Acids Structurally Varied At C-4 And Their Behaviour Towards Sialidase From Vibrio Cholerae", Liebigs Annalen Der Chemie, No. 2, Feb. 1991, pp. 129-134.
Palese et al. 81CA:99310h 1974.
Dernick et al. 96CA:81804x 1982.
Schulman et al. 82 CA: 119464n 1975.
Mack et al., "Synthesis Of 6-Thiosialic Acids And 6-Thio-N-Acetyl-D-Neuraminic Acid", Pergamon Journals Ltd., vol. 28, No. 2, 1987, pp. 191-194.
Nakamura et al., "Studies On Sialic Acids, XV. Synthesis of .alpha.-and.beta.-.sigma.-Glycosides of 3-Deoxy-D-galyceroD-galacto-2-nonulopyranosonic", Chem. Pharm. Bull. 36(12) 4807-4813(1988).
Flashner et al., Arch. Biochem. Biophys., 221(1), 1983, pp. 188-196.
Baumberger et al., Helvetica Chimica Acta, 1988, 71 pp. 429-445.
Czoliner et al., Helvetica Chimica Acta, 1990, 73 pp. 1338-1357.

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