Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Enzymatic production of a protein or polypeptide
Patent
1984-09-27
1988-04-19
Wiseman, Thomas G.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Enzymatic production of a protein or polypeptide
435 70, 4351723, 435253, 435320, 435849, 536 27, 935 41, 935 47, 935 48, C12P 2100, C12P 2102, C12N 1500, C12N 120, C12N 700, C07H 1512
Patent
active
047389214
ABSTRACT:
The present invention comprises improved derivatives of the tryptophan operon useful for expressing fused gene products in E. coli and relate organism. Two of the improved derivatives disclosed are encoded on 0.43 and 0.55 kb EcoRI restriction fragments from plasmids pCZ20 and pLEBGH2 (in strains NRRL B-15881 and NRRL B-15882), respectively. The modified derivatives have been placed on recombinant DNA cloning and expression vectors. A variety of expression vectors have been constructed that drive expression of fused gene products. Two novel gene sequences, encoding insulin-like growth factors I and II, have been expressed with the modified tryptophan operon system.
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Belagaje Ramamoorthy
Epp Janet K.
Hoskins JoAnn
Hsiung Hansen M.
Long George L.
Eli Lilly and Company
Levy Ron K.
Mays Thomas D.
Whitaker Leroy
Wiseman Thomas G.
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