Derivative of kanamycin A and a process for the preparation ther

Details Derivative of kanamycin A and a process for the preparation ther Derivative of kanamycin A and a process for the preparation ther

1981-02-18

1982-06-29

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, A61K 3171, C07H 1522

Patent

active

043373364

ABSTRACT:
There are provided new compounds, 3',4'-anhydro-4'-epi derivatives of kanamycin A of the formula: ##STR1## wherein R represents an alkyl, aralkyl or aryl group and Y represents an alkylidene, aralkylidene, cycloalkylidene or tetrahydropyranylidene group which are useful as an intermediate for the synthesis of 3',4'-dideoxykanamycin A and 4'-deoxykanamycin A from kanamycin A. The compounds of formula (I) can be prepared by treating the corresponding 4'-O-sulfonyl derivative with an alkali metal alcoholate in a lower alkanol under an alkaline condition.

REFERENCES:
patent: Re28647 (1975-12-01), Umezawa et al.
patent: 4060682 (1977-11-01), Umezawa et al.
patent: 4078138 (1978-03-01), Akita et al.
patent: 4195170 (1980-03-01), Umezawa et al.

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