Derivative of (-)-6,6-dimethylbicyclo[3.3.1]ept-2-ene-2-methanol

Details Derivative of (-)-6,6-dimethylbicyclo[3.3.1]ept-2-ene-2-methanol Derivative of (-)-6,6-dimethylbicyclo[3.3.1]ept-2-ene-2-methanol

1985-06-07

1986-08-12

Lone, Werren B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568715, 568824, C07C 3518

Patent

active

046057927

ABSTRACT:
A novel derivative of (-)-6,6-dimethylbicyclo[3.3.1]ept-2-ene-2-methanol is disclosed.
The compound which is an object of the present invention, is the derivative :.alpha.,.alpha.-dimethyl-5-hydroxy-3-cyclohexene-1,4-dimethanol.
The present invention further discloses the process for obtaining the compound which consists in preparing the (-)-6,6-dimethylbicyclo[3.3.1]ept-2-ene-2-methanol epoxide, thereafter hydrating the above compound and separating the compound from the hydration products. Finally, this invention comprises the pharmaceutical compositions containing the compound which possess a pharmacological mucosecretolytic activity.

REFERENCES:
patent: 2883398 (1959-04-01), Frostixk et al.
patent: 2949489 (1960-08-01), Durbetaki et al.
Ventura et al., "Chemical Abstracts" vol. 99 (1983) p. 115465s.
Baib, "J. Amer. Chem. Soc." vol. 68, pp. 638-642.
P. Ventura, M. Schiavi and S. Serafini, "The Metabolism of Trans-Sobrerol in the Rat", Xenobiotica, 1983, vol. 13, No. 3, pp. 139-146.

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