Organic compounds -- part of the class 532-570 series – Organic compounds – Oxygen containing
Patent
1985-06-07
1987-02-17
Lone, Warren B.
Organic compounds -- part of the class 532-570 series
Organic compounds
Oxygen containing
568824, 568715, C07C 3518
Patent
active
046440879
ABSTRACT:
A novel derivative of (-)-6,6-dimethylbicyclo [3.1.1]ept-2-ene-2-ethanol (J. P. Bain, J. Am. Chem. Soc. 1946, vol. 68, page 638) is disclosed. The parent composition is marketed e.g. under the name nopol, v. The Aldrich-Europe Catalog Handbook of Fine Chemicals, item 3160-5 nopol 98% 128-50-7.
The object of the present invention is the compound of formula (I): 4-(2-hydroxyethyl) -.alpha..alpha.dimethyl-5-hydroxy-3-cyclohexene-1-methanol, with the process for obtaining the same, which consists of the preparation of (-)-(6,6-dimethylbicyclo[3.1.1]ept-2-ene-2-ethanol epoxide, followed by hydration of the above compound. Finally, this invention comprises the pharmaceutical compositions containing the compound of formula (I) which have a mucosecretolytic pharmacological activity.
REFERENCES:
patent: 2815378 (1957-12-01), Klein
P. Ventura, M. Schiavi and S. Serafini, "The Metabolism of Trans-Sobrerol in the Rat", Xenobiotica, 1983, vol. 13, No. 3, 139-146.
Ventura et al, "Chemical Abstracts", vol. 99, (1983) p. 115465s.
Bain, "J. Amer. Chem. Soc.", vol. 68, pp. 638-642, (1946).
Camillo Corvi S.p.A.
Lone Warren B.
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