Depth selective pH measurement and UV exposure measurement

Details Depth selective pH measurement and UV exposure measurement Depth selective pH measurement and UV exposure measurement

2002-02-28

2010-02-02

Lauchman, L. G (Department: 2877)

Optics: measuring and testing

By dispersed light spectroscopy

With raman type light scattering

Reexamination Certificate

active

07656522

ABSTRACT:
A Raman spectrum is measured inside animal tissue, such us human skin tissue, at a selected depth from a surface the tissue. A pH value is computed using a function that assigns a pH value as a function of the measured Raman spectrum. The computation may involve computing a number representing a ratio of concentrations of a protonated and a deprotonated version of a chemical substance from the Raman spectrum and generating pH information on the basis of said number. The chemical substance is for example a form of Urocanic acid (UCA). UV exposure is measured from the weight of the spectrum of cis-UCA.

REFERENCES:
patent: 6542762 (2003-04-01), Alam et al.
patent: 7113814 (2006-09-01), Ward et al.
patent: WO 00 78217 (2000-12-01), None
Caspers P J et al: “In Vivo Confocal Raman Microspectroscopy of the Skin: Noninvasive Determination of Molecular Concentration Profiles”, Journal of Investigative Dermatology, vol. 116, No. 3, Mar. 2001, pp. 434-442, XP002220321 cited in the application p. 436, right-hand column, paragraph 4.

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