Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2006-08-29
2006-08-29
Campell, Bruce R. (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C530S300000, C514S002600, C514S009100
Reexamination Certificate
active
07098186
ABSTRACT:
The present invention relates to a novel compound which is useful as an agent for prevention and treatment of diseases associated with HDAC, in particular, tumor or cell proliferative diseases. The depsipeptide compound or its pharmaceutically acceptable salt of the present invention has a good HDAC inhibitory activity and an inhibitory activity of cell proliferation against human cancer cells and, therefore, is useful in treatment and improvement of diseases and pathogenic conditions associated with histone acetylation, in particular, tumor or cell proliferative diseases.
REFERENCES:
patent: 6670326 (2003-12-01), Nagai et al.
patent: 2003/0082054 (2003-05-01), Grylls et al.
patent: 2001-348340 (2001-12-01), None
patent: WO 00-42062 (2000-07-01), None
D. Voet and J.G. Voet. Biochemistry, 2nd Edition.(1995), p. 58.
Amase Mitsuo
Amino Nobuaki
Mori Masamichi
Nagai Koji
Shindo Nobuaki
Astellas Pharma INC
Campell Bruce R.
Kosar Andrew D.
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