Deprotection of RNA with alkylamine

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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536 253, C07H 100, C07H 2104

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058046836

ABSTRACT:
A method for the deprotection of RNA comprising reacting an alkylamine or ammonium hydroxide/alkylamine mixture with the RNA at 60-70 degrees Centigrade for 5 to 15 minutes in order to remove any exocyclic protecting groups, wherein said alkylamine is selected from the group consisting of ethylamine, propylamine, and butylamine.

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