Deprotection of phosphorus in oligonucleotide synthesis

Details Deprotection of phosphorus in oligonucleotide synthesis Deprotection of phosphorus in oligonucleotide synthesis

2005-11-22

2005-11-22

Wilson, James O. (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S025300

Reexamination Certificate

active

06967247

ABSTRACT:
A process for removing a phosphorus protecting group from a protected phosphate triester or phosphorothioate triester includes contacting a protected phosphate or phosphorothioate triester with a thiol compound that is not offensive to the olfactory senses.

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Copy of the PCT International Search Report dated Oct. 23, 2003 (PCT/US03/22211).
Kumar, R. et al., “The First Analogues of LNA (Locked Nucleic Acids): Phosphorothioate-LNA and 2'-THIO-LNA,”Bioorganic&Medicinal Chem. Letts., 1998, 8, 2219-2222.
Singh, S. K. et al., “Synthesis of 2'-Amino-LNA: A Novel Conformationally Restricted High-Affinity Oligonucleotide Analogue with a Handle,”J.Org.Chem., 1998, 63, 10035-10039.

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