Depolymerized dermatan sulfates endowed with an antithrombotic,

Details Depolymerized dermatan sulfates endowed with an antithrombotic, Depolymerized dermatan sulfates endowed with an antithrombotic,

1989-05-10

1990-11-27

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 21, 536 54, 536 551, 514 56, A61K 31725, C08B 3700, C08B 3710

Patent

active

049735802

ABSTRACT:
Process for the preparation of oligosaccharides by a controlled chemical depolymerization of natural polysaccharides, such as heparins, heparan sulfates, dermatan sulfates, chondroitinsulfates, hyaluronic acid, by a radicalic reaction in an aqueous solution, at a temperature ranging between 20.degree. and 70.degree. C., in the presence of a catalyst selected in the group consisting of Cu++, Fe++, Cr+++, Cr.sub.2 O.sub.7 - as well as the resulting oligosaccharides and their related pharmaceutical compositions. The products exhibit high antithrombotic activity, little or no anticoagulant activity, high fibinolytic activity an antiinflammatory activity.

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Tollefsen; Nouv. Rev. Fr. Hematol., 26:233-237, (1984).

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