Depolymerized and supersulfated heparin, process for its prepara

Details Depolymerized and supersulfated heparin, process for its prepara Depolymerized and supersulfated heparin, process for its prepara

1985-05-24

1988-02-23

Brown, J. R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 21, 514822, A61K 31725, C08B 3710

Patent

active

047270632

ABSTRACT:
Novel depolymerized and supersulfated heparin having a molecular weight comprised between 2000 and 9000 and a sulfation degree of at least 2.5, in which all of the primary hydroxy groups are sulfated; a process for its preparation by reacting a heparin of natural origin, or a fraction thereof with a sulfuric acid/chlorosulfonic acid mixture; and pharmaceutical compositions containing it as active ingredient, having potential antithrombotic, hypolipemic and fibrinolytic activity and useful in the prevention of thrombosis and for the treatment of atherosclerosis.

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