Depolarizing skeletal muscle relaxants

Details Depolarizing skeletal muscle relaxants Depolarizing skeletal muscle relaxants

1994-09-06

1996-04-23

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3144

Patent

active

055103553

ABSTRACT:
Compounds such as 5-chloronicotine, 5-fluoronornicotine, anabaseine, 5-fluoroanabaseine, 2-acetoxymethylquinuclidine or!2-(3-pyridyl)-quinuclidine are useful as locally acting and highly selective muscle relaxants. Each compound, when administered intravenously, acts to bind to musculoskeletal nicotinic receptor sites in a reversible manner causing transient depolarization, and hence provides for reversible muscle relaxation to a patient during anesthesia.

REFERENCES:
patent: 4179507 (1979-12-01), Stenlake et al.
patent: 4190674 (1980-02-01), Grivsky
patent: 4508715 (1985-04-01), Booth et al.
patent: 4701460 (1987-10-01), El-Sayad et al.
patent: 4761418 (1988-08-01), Swaringen, Jr. et al.
patent: 4923898 (1990-05-01), Sunshine et al.
patent: 5015741 (1991-05-01), Osdene et al.
patent: 5242935 (1993-09-01), Lippiello et al.
patent: 5260337 (1993-11-01), Sims et al.
patent: 5276043 (1994-01-01), Lippiello et al.
patent: 5346906 (1994-09-01), Baker et al.
Sadikov et al., "Syntheses Based on Anabasine," pp. 3345-3347 (1962).
Rubtsov et al., "Hofmann Cleavage of 6,9-Diazoniadispiro-(5.2.5.2)Hexadecane Dichloride with Methanolic Potassium Hydroxide," pp. 624-630 (1964).
Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, "Cholinergic Agonists," Chapter 5, pp. 91-99, Sixth Edition (1980).
Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, "Anticholinesterase Agents," Chapter 6, pp. 100-119, Sixth Edition (1980).
Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, "Neuromuscular Blocking Agents," Chapter 11, pp. 220-234, Sixth Edition (1980).
Physicians' Desk Reference, 48 Edition, pp. 689-691 (1994), "Anectine".
Physicians' Desk Reference, 48 Edition, pp. 758-760 (1994), "Tracrium Injection".
Physicians' Desk Reference, 48 Edition, pp. 1362-1363 (1994), "Paraflex".
Physicians' Desk Reference, 48 Edition, pp. 1648-1650 (1994), "Norcuron".

Affiliated with

Also associated with

Rating

Depolarizing skeletal muscle relaxants does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Depolarizing skeletal muscle relaxants, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Depolarizing skeletal muscle relaxants will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2308678