Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1993-10-13
1997-11-18
Martinell, James
Chemistry: molecular biology and microbiology
Spore forming or isolating process
536 241, 536 235, C12N 1506, C12N 1512
Patent
active
056886772
ABSTRACT:
A DNA comprising at least one inactivated hormone responsive element and a nucleic acid sequence encoding a membrane-associated protein is described. Therapeutic compositions and cells including the DNA are also described. Other aspects of the invention include methods of treating subjects having cystic fibrosis which include administering an effective amount of the DNA to subjects having cystic fibrosis such that functional cystic fibrosis transmembrane conductance regulator is produced by the subject at a level which is not detrimental to the subject. The present invention also pertains to a method of introducing the DNA into a cell such that the membrane-associated protein is produced at a level which is not detrimental to the cell and cells produced by this method. Still other aspects of the invention include a method of assaying DNA for the presence or absence of a hormone responsive element in a species in which the hormone responsive element is functional and a method of selectively breeding female transgenic mammals which produce a protein of interest.
REFERENCES:
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Cheng Seng Hing
Ditullio Paul
Ebert Karl M.
Meade Harry M.
Smith Alan Edward
Genzyme Corporation
Martinell James
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