Deoxyribonuclease IIβ proteins and CDNAs

Details Deoxyribonuclease IIβ proteins and CDNAs Deoxyribonuclease IIβ proteins and CDNAs

2005-09-13

2005-09-13

Monshipouri, Maryam (Department: 1652)

Chemistry: molecular biology and microbiology

Vector, per se

C536S063000, C435S196000, C435S252300, C435S325000

Reexamination Certificate

active

06943014

ABSTRACT:
The present invention provides cDNAs encoding deoxyribonuclease IIβ and isolated, purified deoxyribonuclease IIβ proteins. Antibodies against this protein and antisense agents targeted to a cDNA or corresponding mRNA encoding deoxyribonuclease IIβ are provided. In addition, methods of identifying and using modulators of deoxyribonuclease IIβ activity are described.

REFERENCES:
Barry et al., “Activation of Programmed Cell Death (Apoptosis) By Cisplatin, Other Anticancer Drugs, Toxins and Hyperthermia”,Biochem. Pharmacol. 1990 40:2353-2362.
Sorenson et al., “Analysis of Events Associated With Cell Cycle Arrest G2Phase and Cell Death Induced by Cisplatin”,J. Natl Cancer Inst. 1990 82:749-755.
Barry, M.A. and Eastman, A., “Identification of Deoxyribonuclease II as an Endonuclease Involved in Apoptosis1,2”,Archives of Biochem and Biophys. 1993 300 (1) :440-450.
Cohen, J.J. and Duke, R.C., “Glucocorticoid Activation of a Calcium-Dependent Endonuclease in Thymocyte Nuclei Leads to Cell Death1”,J. Immunol. 1984 132:38-42.
Eastman, A., “Deoxyribonuclease II in apoptosis and the significance of intracellular acidification”,Cell Death and Differentiation1994 1:7-9.
Kaufmann, S.H., “Induction of Endonucleolytic DNA Cleavage in Human Acute Myelogenous Leukemia Cells by Etoposide, Camptothecin, and Other Cytotoxic Anticancer Drugs: A Cautionary Note”,Cancer Res. 1989 49:5870-5878.
Lennon et al., Induction of apoptosis (programmed cell death) in Tumour cell lines by widely diverging stimuli,Biochem. Soc. Trans. 1990 18:343-345.
Enari, M. et al., “A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD”, 1998 Nature 391:43-50.
McConkey et al., “Interleukin 1 Inhibits T Cell Receptor-mediated Apoptosis in Immature Thymocytes”,J. Biol. Chem. 1990 265: 3009-3011.
McConkey et al., “2,3,7,8-Tetrachlorodibenzo-p-dioxin Kills Immature Thymocytes by Ca2+-Mediated Endonuclease Activation”,Science1988 242:256-259.
Peitsch et al., “Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death)”,EMBO J. 1993 12:371-377.
Rodriguez-Tarduchy et al., “Regulation of apoptosis in interleukin-3-dependent hemopoietic cells by interleukin-3 and calcium ionophores”,EMBO J. 1990 9:2997-3002.
Takano et al., “Apoptosis Induced by Mild Hyperthermia in Human and Murine Tumour Cell Lines: A Study Using Electron Microscopy and DNA Gel Electrophoresis”,J. Pathol. 1991 163:329-336.
Torriglia, et al., “Involvement of DNase II in Nuclear Degeneration during Lens Cell Differentiation”, J. Biol. Chem. 1995 270: 28579-28585.
Wyllie, A.H., et al., “Cell Death: The Significance of Apoptosis”,Int. Rev. Cytol. 1980 68:251-306.
Tanuma, S. and Shiokawa, D., “Cloning of a cDNA Encoding a Rat DNase II-like Acid DNase”,Biochemical and Biophysical Research Communications1999 285:395-399.
Shiokawa D. and Tanuma S., “DLAD, a novel mammalian divalent cation-independent endonuclease with homology to DNase II”,Nucleic Acids Res. 1999 27 (20) :4083-4089.

Affiliated with

Also associated with

Rating

Deoxyribonuclease IIβ proteins and CDNAs does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Deoxyribonuclease IIβ proteins and CDNAs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Deoxyribonuclease IIβ proteins and CDNAs will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3400964