Deoxynarasin antibiotics

Details Deoxynarasin antibiotics Deoxynarasin antibiotics

1978-10-27

1979-11-13

Rosen, Sam

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

Lipid or oil

A61K 3135

Patent

active

041744047

ABSTRACT:
Deoxynarasin antibiotic complex, comprising 20-deoxynarasin and 20-deoxy-epi-17-narasin, is produced by submerged aerobic fermentation of Streptomyces aureofaciens NRRL 11181. 20-Deoxynarasin and 20-deoxy-epi-17-narasin are separated and isolated by chromatography. The deoxynarasin complex, 20-deoxynarasin and 20-deoxy-epi-17-narasin are antibacterial and anticoccidial agents and also increase feed-utilization efficiency in ruminants. 20-Deoxynarasin and its salts are cardiotonic agents.

REFERENCES:
patent: 3947586 (1976-03-01), Messersmith
patent: 3985893 (1976-10-01), Holland et al.
patent: 4038384 (1977-07-01), Berg et al.
Shibata et al.-Chem. Abst., vol. 86 (1977), p. 53912f.
Westley et al.-J. Antibiotics, vol. 30, (7) pp. 610-612 (1977).
Westley et al.-CRC Handbook of Microbiology, vol. III (1973), pp. 407-411.
Occolowitz et al.--Biomedical Mas Spectrometry (1976), 3, pp. 272-277.
Seto et al., J. Antibiotics, vol. 30 (6), pp. 530-532 (1977).
Japanese Unexamined Specification No. 1086-1091 (Derwent No. 69452x).

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