Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof
Patent
1995-04-28
1998-07-14
Killos, Paul J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acids and salts thereof
568439, 568440, 514589, 514700, C07C 6334
Patent
active
057806756
ABSTRACT:
The invention provides deoxygossylic compounds having useful biological activities, and methods for the synthesis of these and related compounds. The invention further provides valuable intermediates for the synthesis of the compounds, and pharmaceutical compositions containing biologically active compounds according to the invention.
REFERENCES:
patent: 4806568 (1989-02-01), VanderJagt et al.
patent: 5026726 (1991-06-01), VanderJagt et al.
CA 121: 11825 (1993).
CA 122: 81663 (1994).
CA 76: 113018 (1971).
CA 122: 80802 (1994).
"Gossypol, A Pigment of Cottonseed", Adams et al, Chem. Rev. 60: 555-574, 1960.
"Biologically Active Derivatives of Gossypol: Synthesis and Antimalarial Activities of Peri-Acylated Gossylic Nitriles", R.E. Royer et al, J. Med Chem 26: 1799-1801 (1986).
"Inhibition of Human Immunodeficiency Virus Type I Replication by Derivatives of Gossylic", R.E. Royer et al, Pharm. Res. 24: 407-412 (1991).
"Efficient Synthesis of the Gossypol Binapthyl Backbone", M.C. Venuti, J. Org. Chem 46: 3124-3127 (1981).
"Synthesis of Apogossypol Hexamethyl Ether", J.D. Edwards, Jr. et al, JACS 79:, 2283-2285 (1957).
"Improved Synthesis of 1,2-Dimethoxy-3-Isopropylbenzene and General Synthesis of 3-Substituted-1,2-Dimethoxy-benzenes", L.M. Deck et al, Org. Prep. Proc. Int. 22: 495-500 (1990).
"Orientation in Aromatic Substitution", J.D. Edwards, JACS 78: 3821-3824 (1956).
"A Conveninet Synthesis of the Important Retinoid Synthon Ethyl Trans-3-Formyl-2-Butenoate", R.W. Curley, Jr. et al, Syn. Commun. 16: 627-631 (1986).
"Factors Determining the Course and Mechanisms of Grignard Reactions", M.S. Kharasch et al, JACS 63: 2316-2320 (1941).
"Action du chlorure cobalteux anhydre, et du nitrate d'uranyl deshydrate sur quelques organomagnesiens et organolithiens aromatiques", Jean-Pierre Morizur, Bull. Soc. Chim. Fr.: 1331-1337 (1964).
"Synthesin aromatischer Aldehyde mit Dichlormethyl-alkylathern", A. Rieche et al, Chem. Ber. 93: 88-94 (1960).
"Total Synthesis of Insoflavones: Jamaicin, Calopogonium Isoflavone-B, Pseudobaptigenin, and Maxima Substance-B, Friedel-Crafts Acylation Reactions with Acid-ensitive Substrates", P.F. Schuda et al, J. Org. Chem. 52: 1972-1979 (1987).
"Selective Oxidation of Aldehydes to Carboxylic Acids with Sodium Chlorite-Hydrogen Peroxide", E. Dalcandale et al, J. Org. Chem. 51: 567-569 (1986).
"The Cleavage of Ethers with Boron Bromide", F.L. Benton et al, JACS 64: 1128-1129 (1942).
"Oxidative Coupling . . . ", Belletire et al, Tetrahedron Letters 27: 127-130 (1986).
"Gossypol binds to a high-affinity binding site on human serum albumin", R.E. Royer et al, FEBS Lett. 157: 28-30 (1983).
"Development of a Sensitive Quantitative Focal Assay for Human Immumodeficiency Virus Infectivity", B. Chesebro et al, J. Virol. 62: 3779-3778 (1988).
"Binding of Gossypol Derivatives to Human Serum Albumin", R.E. Royer et al, J. Pharm. Sci. 77: 237-240 (1988).
"Polyphosphate as a Synthetic Agent . . .", Kanaoka et al, Chem. Pharm. Bull. 13: 1065-1072 (1965).
Deck Lorraine M.
Royer Robert D.
VanderJagt David L.
Killos Paul J.
The University of New Mexico
LandOfFree
Deoxygossylic compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Deoxygossylic compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Deoxygossylic compounds will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1883287