Deoxyadenosine compounds and methods of making and using the sam

Details Deoxyadenosine compounds and methods of making and using the sam Deoxyadenosine compounds and methods of making and using the sam

1988-07-19

1990-03-13

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 28, 536 29, C07H 19173, C07H 1920

Patent

active

049084410

ABSTRACT:
3'-Acyl-2-chloro-2'-deoxy-5'-adenylic acids (I) as well as a method for their production, pharmaceutical compositions comprising the compounds, and methods of treatment using the compound in dosage forms. The compounds of the invention have pharmacological properties and are useful antimicrobial agents and antitumor agents.

REFERENCES:
D. A. Carson, D. Bruce Wasson, and Ernest Beutler, Proc. Natl. Acad. Sci. U.S.A. vol. 81; pp. 2232-2236, 1984.
Christenson et al, J. Med. Chem, vol. 15(7), pp. 736-739, 1972.
Carson et al.(I), Blood, vol. 62(4), pp. 737-743, 1983.
Carson et al(II), Proc. Nat. Acad Sci. U.S.A., vol. 77(11), pp. 6865-6869, 1980.
Carson et al(IV), Proc. Nat. Acad. Sci. U.S.A., vol. 79, pp. 3848-3852, 1982.

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