Deoxy epothilones and intermediates utilized in the process for

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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549375, 562463, 568448, C07D27730, C07D31906, C07C 5990, C07C 4702

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active

061569054

ABSTRACT:
The invention relates to a process for the production of epothilones and intermediate products within the process.
Epothilones A and B are natural substances, which can be produced by microorganisms, and the taxols have similar properties and are thus of particular interest in pharmaceutical chemistry.

REFERENCES:
patent: 4276217 (1981-06-01), Mukaiyama et al.
patent: 5461169 (1995-10-01), Nicolaou et al.
Julien, Bryan et al, CA 2000: 368562, 2000.
Nicolaou, K. C. et al, CA 2000: 316343, 2000.
Mulzer, Johann et al, CA 132: 293 600, 2000.
Tang, Li et al, CA 132: 289462, 2000.
Sawada, Daisuke et al, CA 132:251011, 2000.
Buchmann, Bernd et al, CA 132:64110, 2000.
Nicolaou, K.C. et al, CA132:49831, 2000.
Hoefle, Gerhard et al, CA132:49105, 1999.
Vite, Gregory D. et al, CA 131: 310502, 1999.
Vite, Gregory D. et al, CA 131: 310501, 1991.
Grubbs, R.H. et al., Acc. Chem. Res., vol. 28, pp. 446-452 (1995).
Gerth, K. et al., J. Antibiot., vol. 49, No. 6, pp. 560-563 (1996).
Bollag, M.D. et al., Cancer Res., vol. 55, pp. 2325-2333 (1995).
Meyers, A.I. et al., J.Org.Chem., vol. 38, pp. 2136-2143 (1973).
Keller-Schierlein, W. et al., Helv.Chim.Acta., vol. 4, pp. 1253-1261 (1983).
Nerdel, F. et al., Chem.Ber., vol. 100, pp. 720-735 (1967).
Balog, A. et al., Angew.Chem.Int.Ed.Engl., vol. 35, No. 23/24, pp. 2801-2803 (1997).
Meng, D. et al., J.Am.Chem.Soc., vol. 119, No. 11, pp. 2733-2734 (1997).
Taylor, R.E. et al., Tetrahedron Letters, vol. 38, No. 12, pp. 2061-2064 (1997).
Yang, Z. et al., Angew.Chem.Int.Ed.Engl., vol. 36, No. 1/2, pp. 166-168 (1997).
Blechert, S. et al., Liebigs Ann.Chem., pp. 2135-2140 (1996).
Meng, D. et al., J.Org.Chem., vol. 61, No. 23, pp. 7998-7999 (1996).
Bertinato, P. et al., J.Org.Chem., vol. 61, No. 23, pp. 8000-8001 (1996).
Nicolaou, K.C. et al., Angew.Chem.Int.Ed.Engl., vol. 35, No. 20, pp. 2399-2401 (1996).
Meng et al., J.Am.Chem.Society, vol. 119, pp. 10073-10092 (1997).
Nicolaou et al., Nature, vol. 387, pp. 268-272 (1997).
Nicolaou et al., J.Am.Chem.Soc., vol. 199, pp. 7974-7991 (1997).
Balog et al., Tetrahedron Lett., vol. 38, No. 26, pp. 4529-4532 (1997).
Su et al., Angew.Chem.Int.Ed.Engl., vol. 36, No. 19, pp. 2093-2096 (1997).
Chemical Abstract of WO 98/22461.
Doubleday, C. Jr., Chem. Phys. Letters, vol. 77, No. 1, pp. 131-134 (1981).
Goldsmith, D.J., et al., Tetrahedron Letters, No. 13, pp. 1215-1217 (1967).

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