Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-04-17
2007-04-17
Owens, Amelia A. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C549S346000, C549S354000
Reexamination Certificate
active
10543117
ABSTRACT:
The present invention relates to a new deoxoartemisinin dimer and trimer, which have excellent anticancer activity and lower toxicity and are stable to acids, to a new deoxoartemisinin monomer of intermediate thereof, to preparations thereof, and to anticancer agents comprising the deoxoartemisinin dimer or trimer.
REFERENCES:
patent: WO 93/08195 (1993-04-01), None
Jung, M et al, Antitumor Activity of Novel Deoxoartemisinin Monomers, Dimers, and Trimer, J. Med. Chem. 2003, 46, 987-994.
Efferth, T, Mechanistic perspectives for 1,2,4-trioxanes in anti-cancer thereapy, Drug Resistance Updates 8 (2005) 85-97.
1st Citation in ISR, 1993, Ognyanov et al.
2nd Citation in ISR, Mar. 13, 2003, Jung et al.
Bame James E.
Industry-Academic Cooperation Foundation - Yonsei University
IPLA P.A
Owens Amelia A.
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